Title: Recent progress in fluctuation theorems and free energy recovery
Abstract:
Recent developments in micro and nanotechnologies enable the
manipulation of single molecules one at a time. Single molecule
experiments make possible to resolve energy processes with
unprecedented detail at the level of 1 kT, the typical energy scale of
Brownian fluctuations. Fluctuation theorems establish relations
governing energy exchange processes at this level and provide new
methodologies to obtain equilibrium information from non-equilibrium
experiments. In this chapter we show applications to free energy
recovery in single molecule experiments obtained in our laboratory
(Small biosystems lab, Barcelona, Spain) in unzipping experiments
carried out on DNAs, RNAs and proteins. The range of applications
covers free energy recovery of molecular native, intermediate and
misfolded states as well as peptide-DNA binding interactions.
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