Population Optimum Design of Experiments

PODE 2015

Isaac Newton Institute for Mathematical Sciences, Cambridge

7 July 2015


9.30 - 10.00


10.00 - 10.05


10.05 - 11.00

France Mentre, INSERM, Paris

10 years of progress in population design methodology and applications (slides).

Sergei Leonov, Tobias Mielke, ICON Clinical Research

Optimal design and parameter estimation for population PK/PD models (slides).

11.00 - 11.30





11.30 - 12.30

Marie-Karelle Riviere, INSERM, Paris

Evaluation of the Fisher information matrix in nonlinear mixed effects models using Monte Carlo Markov Chains (slides).

Sebastian Ueckert, INSERM, Paris

Computation of the Fisher information matrix for discrete nonlinear mixed effects models.

12.30 - 14.00






14.00 - 15.30


Tim Waite, University of Southampton

Design for generalized linear models with random block effects (slides).

Steve Gilmour, University of Southampton

Design and analysis of in-vitro pharmacokinetic experiments (slides).

Moreno Ursino, INSERM, Paris

Incorporating pharmacokinetic information in phase I studies in small populations (slides).

15.30 - 16.00





16.00 - 17.00

Andy Hooker, Uppsala University

Model based adaptive optimal designs of adult to children bridging studies using FDA proposed stopping criteria (slides).

Valerii Fedorov, Innovation Center, ICON plc.

Cost constrained optimal design for regression models with random parameters (slides).

17.00 - 17.30


~ PODE ~