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Basel Modelling and Simulation Seminar and PODE 2014 Roche, Basel, 11 September 2014 |
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8.30 - 8:50 |
Welcome and Registration |
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Session
1 |
M&S Seminar Optimal
Design Strategy to Support More Informative Studies in Drug Development |
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8.50 - 10.40 |
Nicolas
Frey,
Roche Introduction |
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France
Mentre, Paris Diderot University Importance
of model based optimal designs to design successful PKPD clinical trials (Slides) |
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Kabir Soeny, Queen Mary University of London and Thomas Bouillon, Novartis Combination
of drugs for infectious diseases: optimal design for the choice of dose (slides) |
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10.40 - 11.10 |
Tea/Coffee |
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Session
2 |
M&S Seminar Optimal
Design Strategy to Support More Informative Studies in Drug Development |
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11.10 - 12.30 |
Andreas
Krause,
Actelion Adaptive
dose selection in phase 1: MTD estimation and efficacy/safety balancing in
entry into man studies |
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Alun
Bedding,
Roche Dose
finding - is it optimal? Experiences of using optimal and adaptive designs
for dose finding (slides) |
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12.30 - 13.30 |
Lunch |
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Session
3 |
PODE 2014 |
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13.30 - 15.00 |
Thu Thuy Nguyen, CEA, Saclay, France Optimal sampling times for pharmacokinetic modelling of a cocktail of phenotyping
drugs (Abstract, Slides) |
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Giulia Lestini, IAME, UMR1137, INSERM and University Paris
Diderot, France Influence of the size of the cohorts in adaptive
design for nonlinear mixed effect models: an evaluation by simulation
for a PK and PD model in oncology (Abstract Slides) |
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Sebastian Ueckert, University of Uppsala, Sweden Fisher
information matrix based power calculations for non-linear mixed effect
models (Abstract Slides) |
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15.00 - 15.30 |
TEA/COFFEE |
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Session
4 |
PODE 2014 |
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15.30 - 16.30 |
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Roger Jelliffe, Laboratory of Applied Pharmacokinetics, Childrens Hospital of Los Angeles Los Angeles, California Experiment design based on Bayes
risk and weighted Bayes risk with application to
pharmacokinetic systems (Abstract Slides) |
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Yasunori Aoki, University of Uppsala, Sweden A tale of
introducing optimal design to preclinical experimentalists (Abstract PopED lite) |
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16.30 - 17.00 |
Joint
Discussion |
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~ PODE ~ |
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