PODE 2010

Population Optimum Design of Experiments: Workshop

Bayer Schering Pharma AG, Berlin

11/12 June 2010


Friday, 11 June



Session 1

14.30 - 15.00

Approximations of the population Fisher information matrix - differences and consequences (slides)

Joakim Nyberg, Sebastian Ueckert and Andrew C. Hooker

Department of Pharmaceutical Biosciences, Uppsala University, Sweden

15.00 - 15.30

Optimization of sampling times for PK/PD models: approximation of elemental Fisher information matrix (slides)

Valerii V. Fedorov, Sergei L. Leonov

GlaxoSmithKline, Collegeville, U.S.A.

15.30 - 16.00

Application of Quasi-Newton Algorithms in Optimal Design (slides)

Sebastian Ueckert, Joakim Nyberg and Andrew C. Hooker

Department of Pharmaceutical Biosciences, Uppsala University, Sweden

16.00 - 16.30

Coffee break

Session 2

16.30 - 17.00

Optimal design and QT-prolongation detection in oncology studies (slides)

Sylvain Fouiliard, Marylore Chenel

Department of Clinical Pharmacokinetics, Institut de Recherches Internationales Servier, France

17.00 - 17.30

Design evaluation and optimisation in crossover pharmacokinetic studies analyzed by nonlinear mixed effects models (slides)

Thu Thuy Nguyen, Caroline Bazzoli, France Mentre

UMR738 INSERM and University Paris Diderot, Paris, France

17.30 - 18.00

D-optimal Adaptive Bridging Studies in Pharmacokinetics (slides)

Lee-Kien Foo, Stephen Duffull

University of Otago, New Zealand

Saturday, 12 June


Session 3

9.30 - 10.00

Design Evaluation and Optimization for models of Hepatitis C viral dynamics (slides)

J. Guedj (1), C. Bazzoli (2), A.U. Neumann (3), F. Mentre (2)

(1)Los Alamos National Laboratory, New Mexico, USA; (2) INSERM, UMR 738 Paris, France; (3)Bar-Ilan University, Ramat-Gan, Israel

10.00 - 10.30

Noninferiority trial designs for odds ratios and risk differences (slides)

Joan F. Hilton

University of California San Francisco

10.30 - 11.00

Optimum designs for nonlinear mixed effects model in the presence of covariates (slides)

Barbara Bogacka

Queen Mary, University of London, UK

11.00 - 12.00

General Discussion, future meetings

~ PODE ~