PODE 2009

Population Optimum Design of Experiments: Workshop

Pavlov State Medical University, St Petersburg, Russia

June 27, 2009


9.00 - 9.10


Session 1: Statistical Developments and Optimisation algorithm

Chair: France Mentre

9.10 - 10.10

Comparison of software tools for population optimal designs

France Mentre, Caroline Bazzoli (Universite Paris Diderot)

10.10 - 10.45


Session 2

Chair: Stephen Duffull

10.45 - 11.05

Optimal design for models with semi-parametric distributions (abstract)

Stefanie Hennig, Andrew Hooker and Joakim Nyberg (Uppsala University)

11.05 - 11.35

Autocorrelation reduces sample time clustering in optimal design (abstract)

Andrew C. Hooker, Joakim Nyberg, Richard Hoglund, Martin Bergstrand and Mats O. Karlsson

(Uppsala University)

11.35 - 12.05

Estimation of Population Pharmacokinetic Measures and Selection of Sampling Times (abstract, slides)

Valerii Fedorov, Sergei Leonov (GlaxoSmithKline)

12.05 - 13.30


Session 3

Chair: Leon Aarons

13.30 - 14.00

Adaptive designs for simultaneous optimization of PK modeling and dose-selection in Phase I clinical trials (abstract, slides)

Maciej Patan and Barbara Bogacka (University of Zielona Gora and Queen Mary, University of London)

14.00 - 14.30

Dose Individualization for High-Dose Anti-Cancer Chemotherapy (abstract, slides)

Gary Rosner (MD Anderson Cancer Center)

14.30 - 15.00

Best intention sequential designs in clinical trial studies (abstract)

Valerii Fedorov, Andrey Pepelyshev, Luc Pronzato, Anatoly Zhigljavsky

(GlaxoSmithKline, University of Sheffield, Universite de Nice Sophia Antipolis and Cardiff University)

15.00 - 15.30


Session 4

Chair: Barbara Bogacka

15.30 - 16.00

Population models in design and analysis of dose finding experiments for binary responses (abstract, slides)

Valerii Fedorov (GlaxoSmithKline)

16.00 - 16.30

Optimum Design for Very Sparse Sampling in Population Models (abstract, slides)

Tobias Mielke, Rainer Schwabe (Otto von Guericke University Magdeburg)

Session 5

Chair: Sergei Leonov

16.30 - 17.00

General Discussion, future meetings

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