PODE 2008

Population Optimum Design of Experiments: Workshop

University Paris Diderot, France

June 23rd, 2008




Session 1: Statistical Developments and Optimisation algorithm

Chair: Steve Dufful

9.15 - 9.45

Rainer Schwabe: General considerations about designs for mixed models illustrated by very simple examples and potential implications to PPK designs. (slides)

9.45 - 10.15

Joakim Nyberg: Different approximations and methods for calculating the FIM and their consequences. (slides)

10.15 - 10.45

Bruno Boulanger, Jonathan Jaeger, Astrid Jullion: BAST: Development of a Bayesian adaptive sampling time strategy for PK studies. (slides)

10.45 - 11.15


Chair: Basia Bogacka

11.15 - 11.45

Kay Ogungbenro: An effective approach for obtaining optimal sampling windows for population pharmacokinetic experiments. (slides)

11.45 - 12.15

Steve Dufful: Highly accurate and rapid solutions for models defined as ODEs.

12.15 - 13.15


Session 2: Application of optimal design in drug development and academia

Chair: Leon Aarons

13.15 - 13.45

Sergei Leonov: Optimization of sampling times for a combined PK/PD model: optimal design as a reference point. (slides)

13.45 - 14.15

Marylore Chenel: Drug drug interaction predictions with PBPK and optimal sampling design. (slides)

14.15 - 14.45

Andy Hooker: Two applications (glucose-insulin and disease-progression) and the methods that we needed to use to compute these designs. (slides)

14.45 - 15.00


15.00 - 15.30

Caroline Bazzoli, Sylvie Retout, Emmanuelle Comets & France Mentre: Optimal design with cost functions for the pharmacokinetics of AZT and AZT-TP. (slides)

15.30 - 16.00

Mats Karlsson: A search for an ethically attractive dose-finding design for a drug with expected narrow therapeutic interval. (slides)

Session 3: Discussion on Software

Chair: France Mentre

16.00 - 17.00

All authors of software: discussion on the updating of Page 2007 table with software specifications.

All: Discussion on the need to organize software evaluation for PODE09



~ PODE ~