PODE 2007

Population Optimum Design of Experiments: Workshop

Pfizer, 4th of May 2007


9.30 - 10.00

Welcome Tea/coffee


10.00 - 11.00

R. Schwabe (Otto von Guericke University Magdeburg)

The equivalence theorem in optimal design (abstract, slides)

11.00 - 11.30


Theory and Methods

11.30 - 12.00


12.00 - 12.30


12.30 - 13.00



K. Chaloner (University of Iowa)

Design of population studies of HIV dynamics (abstract, slides)

C. Bazzoli1, S. Retout1,2 and F. Mentre1,2 (1. INSERM, 2. AP-HP, Hopital Bichat)

Population design in nonlinear mixed effects multiple responses models: extension of PFIM and evaluation by simulation with NONMEM and MONOLIX (abstract, slides)

M. Patan1, B. Bogacka2 (1. University of Zielona Gora, 2. Queen Mary, University of London

Construction of population designs for nonlinear models via selective random search (abstract, slides)

13.00 - 14.00


Practical Issues

14.00 - 14.15

14.15 - 14.30

14.30 - 14.45

14.45 - 15.00

15.00 - 15.15



P. Johnson (Pfizer)

Optimal dose & sample-size selection for dose-response studies (abstract, slides)

K. Ogungbenro, M. Chenel and L. Aarons (University of Manchester)

Optimal design for drug-drug interaction study using PopDes - application to SX and MDZ (abstract, slides)

G. Hegarty1, J. McGree2, S.Duffull1 (1. University of Otago, 2. University of Queensland)

Rescuing a population PK study and assessing its performance for covariate identification (abstract, slides)

I. Gueorguieva and K. Jackson (Lilly Research Centre)

Prospective application of a multivariate population optimal design to determine parent and metabolite pharmacokinetic sampling times in a Phase II study (abstract, slides)

G. Graham (Pfizer)

Examples of the application of optimum design to nonlinear mixed effects models at Pfizer (abstract, slides)

15.15 - 15.45


Software Session

15.45 - 16.10


16.10 - 16.35


16.35 - 17.00


17.00 - 17.25


17.25 - 17.50



S. Duffull (University of Otago)

Walking with WinPOPT (abstract, slides)

S. Retout1, 2, C. Bazzoli1, E. Comets1, H. Le Nagard1, F. Mentre1, 2 (1. INSERM, 2. AP-HP, Hopital Bichat)

Population designs evaluation and optimisation in R: the PFIM function and its new features (abstract, slides)

K. Ogungbenro, I. Gueorguieva, G. Graham and L. Aarons (University of Manchester)

PopDes - an optimal experimental design program for individual and population uniresponse and multiresponse PKPD models (abstract, slides)

A. Hooker (Uppsala University)

Population optimal experimental design using PopED (Population optimal Experimental Design) (abstract, slides)

S. Leonov (GlaxoSmithKline)

PkStaMp - optimal designs for compartment models (abstract, slides)

17.50 - 18.00



18.00 - 18.30



Lead by France Mentre (INSERM and AP-HP, Hopital Bichat)

~ PODE ~