Abstract Metzler: Anomalous diffusion in membranes and cytoplams of biological cells
A surging amount of experimental and simulations studies reveals persistent
anomalous diffusion in both cellular membranes and the cytoplasm [1,2]. The
anomalous diffusion is observed for micron-sized objects down to labelled
single molecules such as green fluorescent proteins [3].
This talk will first present results from large scale computer simulations
and stochastic analysis of the motion of lipids and embedded proteins in
lipid bilayer model membranes [4], indicating that increased disorder leads
to longer and longer lasting anomalous diffusion. In particular, the motion
of lipids and proteins can become non-Gaussian [4]. In the membranes of living
cells anomalous diffusion of embedded protein channels can last over several
hundreds of seconds [5]. In particular, this anomalous diffusion can become
non-ergodic and exhibit ageing, two topics explained and discussed in this
talk [6].
The findings of anomalous diffusion in membranes will be complemented by a
brief summary of anomalous diffusion in the cellular cytoplasm, referring to
both subdiffusion of passive tracers and superdiffusion due to active
motion in cells.
[1] K. Norregaard, R. Metzler, C. Ritter, K. Berg-Sorensen, and L.
Oddershede, Chem. Rev. 117, 4342 (2017).
[2] F. Hofling and T. Franosch, Rep Progr Phys 76, 046602 (2013).
[3] C Di Rienzo, V Piazza, E Gratton, F Beltram, and F Cardarelli, Nature Comm
5, 5891 (2014).
[4] J-H Jeon, HM-S Monne, M Javanainen, and R Metzler, Phys Rev Lett 109,
188103 (2012); J-H Jeon, M Javanainen, H Martinez-Seara, R Metzler, and
I Vattulainen, Phys Rev X 6, 021006 (2016).
[5] AV Weigel, B Simon, MM Tamkun, and D Krapf, Proc Natl Acad Sci USA 108,
6438 (2011).
[6] R Metzler, J-H Jeon, AG Cherstvy, E Barkai, Phys Chem Chem Phys 16 24128
(2014).