PODE 2008 Population Optimum Design of Experiments:
Workshop University June 23rd, 2008 |
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9.00-9.15 |
Welcome |
Session 1: Statistical
Developments and Optimisation algorithm Chair: Steve Dufful |
|
9.15 - 9.45 |
Rainer Schwabe: General considerations about designs for mixed models illustrated by very simple examples and potential implications to PPK designs. (slides) |
9.45 - 10.15 |
Joakim Nyberg: Different approximations and methods for calculating the FIM and their consequences. (slides) |
10.15 - 10.45 |
Bruno Boulanger, Jonathan Jaeger, Astrid Jullion: BAST: Development of a Bayesian adaptive sampling time strategy for PK studies. (slides) |
10.45 - 11.15 |
Break |
Chair: Basia Bogacka |
|
11.15 - 11.45 |
Kay Ogungbenro: An effective approach for obtaining optimal sampling windows for population pharmacokinetic experiments. (slides) |
11.45 - 12.15 |
Steve Dufful: Highly accurate and rapid solutions for models defined as ODEs. |
12.15 - 13.15 |
Lunch |
Session 2: Application of
optimal design in drug development and academia Chair: Leon Aarons |
|
13.15 - 13.45 |
Sergei
Leonov: Optimization of sampling times for a combined
PK/PD model: optimal design as a reference point. (slides) |
13.45 - 14.15 |
Marylore
Chenel: Drug drug interaction predictions with PBPK and
optimal sampling design. (slides) |
14.15 - 14.45 |
Andy
Hooker: Two applications (glucose-insulin and
disease-progression) and the methods that we needed to use to compute these
designs. (slides) |
14.45 - 15.00 |
Break |
15.00 - 15.30 |
Caroline
Bazzoli, Sylvie Retout, Emmanuelle Comets & France Mentre:
Optimal design with cost functions for the pharmacokinetics of AZT and
AZT-TP. (slides) |
15.30 - 16.00 |
Mats
Karlsson: A search for an ethically attractive dose-finding
design for a drug with expected narrow therapeutic interval. (slides) |
Session 3: Discussion on
Software Chair: |
|
16.00 - 17.00 |
All authors of software: discussion on the updating
of Page 2007 table with software specifications. All: Discussion on the need to organize software
evaluation for PODE09 |
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~ PODE ~ |